6 of the Best Fruits to Boost Your Immunity This Winter, According to Nutritionists

Help keep sickness at bay with these tasty immune-supporting fruits.

A platter of assorted fruits including kiwi strawberries mango cubes pomegranate seeds and blueberries arranged in sections
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Key Takeaways

  • Fruits rich in vitamin C, like kiwi, oranges, and grapefruit, help strengthen immune defenses and reduce inflammation.
  • Antioxidant-rich fruits such as pomegranate, blueberries, and mango protect cells and support gut health, where most immune activity occurs.
  • Eating a variety of colorful fruits provides essential vitamins that help immune cells develop, communicate, and respond effectively.

Eating the best fruits for immunity can help keep you healthy, no matter the time of year. But it’s even more important during the winter months because cold, dry air and more time spent indoors can make it easier for viruses to spread and challenge your body’s natural defenses.

By consuming more fruits (and practicing other healthy lifestyle habits, such as regular exercise and adequate sleep), you can reduce your risk of getting sick. And while all fruits can benefit health and immunity, some are particularly helpful. Curious? We asked registered dietitians to share their top picks for immune-boosting fruits, as well as ideas for enjoying them.

Kiwi

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Credit: David Malosh

"Kiwis are an excellent source of vitamin C, which is essential for supporting white blood cell production and fighting off infections," says Lauren Manaker, MS, RDN, LD, registered dietitian and founder of Nutrition Now Counseling. "They also contain vitamin K and antioxidants that support overall health and help reduce inflammation," notes Manaker.

How to Eat

Orange

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Credit: Janelle Jones

"Oranges have vitamin C, which helps strengthen the immune system by protecting the cells in your body," says Jennifer Hillis, MS, RDN, LDN, registered dietitian and citrus nutrition research liaison at University of South Florida College of Public Health. Furthermore, the citrus fruits contain potassium, folate, and thiamin, which help support overall immune function, says Hillis. Oranges also have hesperidin, a plant compound that's primarily found in citrus, says Hillis. Hesperidin provides "numerous benefits that support the immune system thanks to its antioxidant and anti-inflammatory properties," says Hillis.

How to Eat

  • "Keep it simple by pairing orange slices with Greek yogurt for a balanced snack that combines protein, fiber, and essential nutrients," says Hillis.
  • Add 100 percent orange juice to chili, where it will add brightness and nutrient density, she suggests.
  • "You can also use 100-percent orange juice in dressings or marinades to brighten up dinners and meal prep," notes Hillis.

Pomegranate

one whole pomegranate and one broken into quarters on a blue plate with a knife
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Getty / Anna Bogush

Known for their beautiful, deep red color, pomegranates are another fruit that can boost your immunity this winter. "Pomegranates are rich in antioxidants, particularly polyphenols, which help reduce inflammation and protect cells from damage," says Manaker. They also contain vitamin C and fiber, a nutrient that aids in gut health. This is important because gut health is critical for good immunity, according to Seema Shah, MPH, MS, RD, registered dietitian and owner of SeemaShahRD Whole Nutrition.

How to Eat

It's worth learning how to cut a pomegranate and remove the seeds, though you can buy the seeds in stores.

Mango

sliced mangoes on cutting board with knife
Credit: NICO SCHINCO

"Mango might not be the first food that comes to mind for immunity, but its beautiful, bright orange color tells a different story. The vibrant orange flesh means it contains carotenoids like beta-carotene, the precursor to vitamin A," says Shah. Vitamin A is important for immunity, as it supports immune cells' development and responsiveness, according to Shah. Mango is also high in other immune-boosting, inflammation-lowering nutrients, such as vitamin C, vitamin E, and folate, says Shah.

How to Eat

Blueberries

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Credit: Frederic Lagrange

The high fiber and phytochemical content of blueberries fuels good gut bugs, reduces inflammation, and maintains a strong gut lining, says Shah. This is noteworthy because more than 70 percent of the body’s immune cells are located in the gut, according to Shah. The fiber in blueberries helps slow digestion and support healthy blood sugar control, which may improve insulin sensitivity over time. This matters because chronically high blood sugar levels can impair immune cell function and weaken the body’s ability to fight infection, Shah says. Additionally, blueberries provide antioxidants, vitamin C, and vitamin K, all of which support immune cells.

How to Eat

"Blueberries are best enjoyed frozen or raw to preserve their antioxidant content," says Shah.

  • Toss blueberries in your favorite salad for a punch of flavor and texture.
  • Add blueberries to smoothies, overnight oats, or breakfast cereal, says Shah.
  • Make a simple fruit salad by mixing blueberries, orange wedges, and sliced bananas with a drizzle of honey.
  • Top yogurt (or frozen yogurt bark) with blueberries.

Grapefruit

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Credit: Romulo Yanes
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Grapefruit, like oranges, is packed with immune-supporting vitamin C. It also "has beneficial plant compounds, flavonoids, and carotenoids, which work to support the immune system by fighting inflammation and helping cells communicate with each other," says Hillis. Plus, the citrus fruit contains B vitamins such as folate, thiamin, vitamin B6, and riboflavin, notes Hillis. Not only do these B vitamins work as enzymes involved in immune cell function, but they can also control oxidative stress and inflammatory responses, she says. 

How to Eat

Sources
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  1. Hosseini B, Berthon BS, Saedisomeolia A, et al. Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic review and meta-analysis. Am J Clin Nutr. 2022; published online.

  2. Lo Conte, M., Montini, F. (2025). The Intestine Is an Important Hub for Development and Regulation of Innate and Adaptive Immunity. In: Falcone, M., Antonini Cencicchio, M. (eds) Physical and Biological Barriers at the Interface Between the Gut Microbiome and the Immune System. The Microbiomes of Humans, Animals, Plants, and the Environment, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-031-84065-4_1

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